Welcome to the Cancer Cell Line Factory!

The goal of the Broad Cancer Cell Line Factory is to make it possible to convert any tumor sample into an organoid, cell line, or spheroid model. We are focused both on scale and on increasing diversity. Our models are shared broadly with the scientific community.

The sunburst visualization reflects actual composition of genomically verified CCLF patient models. Colors reflect different tumor types and cohorts.

3,200+

Acquired samples

509

Verified models (unique patients);
Total 699 models

67

Cancer types

40%

Rare/Pediatric

We are committed to five goals

  • Convert any patient tumor sample into a perturbable cell model
  • Fill cancer cell model collection gaps to cover as many tumor types and genotypes as possible
  • Share new patient models broadly
  • Increase the representation of underrepresented ethnicities in patient models available for cancer researchers
  • Integrate ex vivo functional testing into cancer precision medicine workflows

Use this website to:

Browse all genomically verified cancer cell models

Download tissue acquisition, cryopreservation, and other model derivation related SOPs and cell culturing media recipes that the CCLF team has optimized

Collaborate with the CCLF team in model derivation, perturbation feasibility, dependency validation, and new technology development (Email us at cellfactory@broadinstitute.org)